Ive never had anyone able to prove it, who said it does have negatives. And with partitioning you can keep things like yer swap file defraged easy and where physically on the disk its located.
From my experience instability only happens when yer goin the opposite way, disk spanning with software or hardware...and raid 0 especially, which isnt true raid anyways, and has almost no benefits.
Core i7 920 @ 3.8Ghz | 6GB OCZ DDR3 8-8-8-24 @ 1600mhz | eVga x58 Mobo | 2 x eVga GTX 460 SLI | Intel X25-M + 3x Seagate + WD Black = 2.75TB | X-Fi Titanium | PCP&C Silencer 750 | G15 KB | G5 Mouse | G35 Headset | Z-5500 Digital | Samsung T260HD