Any med students/docs/druggies?
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Noob
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PostPosted: Sat, 28th Jul 2007 19:58    Post subject: Any med students/docs/druggies?
I've wondered this for a while, but why can't alcoholics take alcoholic intravenously so as to avoid liver damage. For example, with anabolic-steroids if the athlete takes them via injection (intra muscular though) the liver doesn't get a hammering unlike like with oral 'roids, where it has to go thru the liver.

So is this any different to alcohol?
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nouseforaname
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PostPosted: Sat, 28th Jul 2007 20:04    Post subject:
whatever the reason, seems like it works ... although the authors of this study doesn't talk about liver damage... perhaps there is more to worry about when injecting alcohol than long term effects on the liver ...

INTRAVENOUS INJECTION OF ALCOHOL BY DRUG INJECTORS: REPORT OF THREE CASES
http://alcalc.oxfordjournals.org/cgi/content/full/34/6/918


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Noob
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PostPosted: Sat, 28th Jul 2007 20:26    Post subject:
Interesting, my damn uni credentials expired (damn graduation!) so I have no axxs to journals anymore Sad WOuld be very interested in the liver side of injecting alcohol. I mean, it'd be the best drug ever if it dind't harm you via this method.
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Mortibus




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PostPosted: Sat, 28th Jul 2007 20:58    Post subject:
there is better solution;
not to drink alcohol [well a maybe glass of red wine time after time during meal]
if one cares about his liver so much

alcoholics usually don't give a frack about their health or others, same for hardcore smokers
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Invasor
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PostPosted: Sat, 28th Jul 2007 21:02    Post subject:
I guess it still could harm your brain... Also, what would you inject, vodka? I dont think it is so pure, as in just alcohol and water, so you would probably inject some toxins(or who knows what) too? And injecting beer or whisky (as reported) sound crazy to me.

Quote:
Two other unusual routes of alcohol ingestion have been reported in the media recently, snorting vodka among middle-class English club-goers (Mollard, 1998Go) and the use of vodka-soaked tampons by teenage girls in Eastern Finland (Anonymous, 1999Go). Intravenous injection has some common features with these other methods, e.g. rapid onset of effects, low doses required for intoxication, and the reduced likelihood of recent alcohol consumption being identified.


That reminds me of a tv show I saw, where a guy had a "wine enema"... I think he only felt pain, and the alcohol did nothing lol
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Noob
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PostPosted: Sat, 28th Jul 2007 21:15    Post subject:
Harm your brain? How so? Memory loss? I wasn't planning on injecting vodka or anything. But i'm just thinking out loud that it'd be a good way to solve alcholism and various forms of depression.
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Zino




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PostPosted: Sat, 28th Jul 2007 22:25    Post subject:
Even if you inject alcohol directly into the bloodstream which is a really bad idea the liver will still process it.

What did you think happend to drugs that where injected into the bloodstream, that they would circle your body for all eternity? Smile

The liver detoxifys substances such as alcohol into bile, that is the way the body gets rid of it.
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Noob
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PostPosted: Sat, 28th Jul 2007 22:28    Post subject:
Why is it that when you take anabolic steroids orally it's worse for the liver though? It is to do with them being injected intra-muscular?
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Zino




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PostPosted: Sat, 28th Jul 2007 22:52    Post subject:
Noob wrote:
Why is it that when you take anabolic steroids orally it's worse for the liver though? It is to do with them being injected intra-muscular?


When something is taken orally the dose always has to be higher since the liver will process some of it. Oral substances has to travel to the right destination so it has to pass though the liver, when injected directly into muscles most of it will stay there and only be released in small amounts to the liver.

Btw dont take steroids...
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Jenni
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PostPosted: Sun, 29th Jul 2007 03:05    Post subject:
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SpykeZ




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PostPosted: Sun, 29th Jul 2007 03:16    Post subject:
Jenni wrote:
http://en.wikipedia.org/wiki/Alcohol_without_liquid


weird...getting drunk by breating....So technically wouldn't that harm your lungs than?


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Jenni
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PostPosted: Sun, 29th Jul 2007 03:45    Post subject:
Probably. I mean alcohol is damaging to all life.


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deelix
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PostPosted: Sun, 29th Jul 2007 12:04    Post subject:
Jenni wrote:
http://en.wikipedia.org/wiki/Alcohol_without_liquid
well, you can do what they did in mythbusters. Vodka to steam in a (didn't find out the english word Razz )
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nouseforaname
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PostPosted: Sun, 29th Jul 2007 19:30    Post subject:
deelix wrote:
(didn't find out the english word Razz )


sauna Wink

http://en.wikipedia.org/wiki/Sauna


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Rinze
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PostPosted: Sun, 29th Jul 2007 21:05    Post subject:
The picture is better than the word anyway Razz
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Mortibus




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PostPosted: Sun, 29th Jul 2007 21:57    Post subject:
that picture reminded me ppl from auschwitz

problem is u had to be tortured to get in this kinda ultra skinny shape, now it's just matter of choice, very sad
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Noob
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PostPosted: Sun, 29th Jul 2007 23:24    Post subject:
If you notice her upper thighs, she isn't skinny at all. Good indicator.
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Accelleron




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PostPosted: Mon, 30th Jul 2007 00:57    Post subject:
injecting alcohol can't be popular, because in order to be safe it has to be 100% sterile, med grade alcohol, and unless you work in a hospital, that isn't the easiest thing to get.

Besides, speaking in terms of an alcoholic who, as mortibus said, probably doesn't give a damn about his/her health, buying a $10 bottle of everclear/cheap vodka and drinking it is a hell of a lot cheaper and easier way to get wasted than buying med-grade alcohol and a syringe (which could also pose a problem) and prodding around for a vein in an unsober state.

Noob wrote:
But i'm just thinking out loud that it'd be a good way to solve alcholism and various forms of depression.

I'm not exactly following your logic here. How would intravenous administration of alcohol cure anything, especially alcoholism?


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Noob
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PostPosted: Mon, 30th Jul 2007 07:25    Post subject:
Liver failure, alcholism is only a 'disease' because its effects on the body. Reduce these effects and you merely have social effecs.

According to the PubMed article cited earlier, you can inject vodka. (http://alcalc.oxfordjournals.org/cgi/content/full/34/6/918)

Quote:
He injected mainly vodka, sherry or whisky with approximately a twice-monthly frequency. His last injection had been 2 weeks before admission. He gave the main reasons for this use as the rapid effect and the enjoyment of the injection itself. The only side-effect he described was a burning pain at the site of injection.
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spankie
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PostPosted: Mon, 30th Jul 2007 14:17    Post subject:
Noob wrote:
Why is it that when you take anabolic steroids orally it's worse for the liver though? It is to do with them being injected intra-muscular?


because the steroids dont go into the blood stream if they go intra muscular...

they go inter cellular, go into some cells, the rest is broken down over time. No bloodstream, no processing.

If you take steroids right into the bloodvein, that would suck big time i guess.


Same reason why vaccination need to be repeated when you get a syringe in your but. Small effect, because not directly into the bloodstream. So you need a first injection and a booster injection later, maybe another booster after some time.
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AnimalMother




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PostPosted: Mon, 30th Jul 2007 16:51    Post subject:
spankie wrote:

Same reason why vaccination need to be repeated when you get a syringe in your but. Small effect, because not directly into the bloodstream. So you need a first injection and a booster injection later, maybe another booster after some time.


I thought the booster shots are to maintain a sufficient quantity of memory cells in the immune system to combat any infection by the specific pathogen?

As the immune response to the vaccination material is far less acute then to an actual invasion by the pathogen, the immunity doesn't last indefinitely.


"Techniclly speaking, Beta-Manboi didnt inject Burberry_Massi with Benz, he injected him with liquid that had air bubbles in it, which caused benz." - House M.D

"Faith without logic is the same as knowledge without understanding; meaningless"
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spankie
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PostPosted: Mon, 30th Jul 2007 17:09    Post subject:
well yeah, you are right, but when vaccins would be stronger and more effective, and not injected into the mussles, but directly into your vein, no booster would be needed.

The body detects a very low amount of something that appears to be strange and they make some memory cells. A booster is needed to tell your body, it actually is bad.

With new vaccins, you dont need a booster, because there are so many active compounds flowing in the bloodstream, the body makes sufficient memory cells.

But for example dead virusses, injected in the mussles, have a low mobility, high degradability, no intracellular effects etc. So they are not really active, not interacting with receptors, not triggering secondary effects etc. Thats why you need to train the body a couple of times.

The "new" (2nd and 3th generation) vaccins are much "fancier". 1 injection and you are safe a life time. They make a hepatitis with harmless genes instead of the pathogenicity genes. The virus is swimming around, entering cells, making the protein that is recognised by the immune system, but not harmful itself. So it actually lives, and enters cell. No booster injection is needed.

It is just the same as once you had a flue, you cannot have the same flue again. And no booster was needed to become immune.
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nouseforaname
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PostPosted: Mon, 30th Jul 2007 17:15    Post subject:
I think you guys are talking about the same thing, just with different language.

spankie is talking about needing multiple doses of a vaccine to achieve immunity in the first place, and AM talking about the booster shots you receive after several years after already having developed immunity. In UK/Canada etc the phrase "booster shot" means what AM is talking about Smile


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pistolshrimp
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PostPosted: Sun, 5th Aug 2007 21:09    Post subject:
deelix wrote:
Jenni wrote:
http://en.wikipedia.org/wiki/Alcohol_without_liquid
well, you can do what they did in mythbusters. Vodka to steam in a (didn't find out the english word Razz )



Why does anyone think this person is skinny? If anything she is normal weight. She could lose and still be normal weight.
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deelix
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PostPosted: Sun, 5th Aug 2007 22:24    Post subject:
hmm, she looks skinny to me. Girls dont need to be to skinny imo. Gross to see the bones :\
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Mortibus




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PostPosted: Sun, 5th Aug 2007 22:35    Post subject:
deelix wrote:
hmm, she looks skinny to me. Girls dont need to be to skinny imo. Gross to see the bones :\


see them? wait till u hit them icebergs in fast forward Razz
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compubrain3000




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PostPosted: Sun, 5th Aug 2007 22:58    Post subject: Re: Any med students/docs/druggies?
Noob wrote:
I've wondered this for a while, but why can't alcoholics take alcoholic intravenously so as to avoid liver damage. For example, with anabolic-steroids if the athlete takes them via injection (intra muscular though) the liver doesn't get a hammering unlike like with oral 'roids, where it has to go thru the liver.

So is this any different to alcohol?


Taking alcohol IV would avoid the first pass effect of the liver and thus decrease liver damage, but will increase the damage done by the alcohol to all other organs.
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